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Paolo Gaetani MD - Scientific Advisor

Co-founder of PharmaExceed, Paolo Gaetani MD has a distinguished international profile and co-leads several research initiatives, in investigating the efficacy and the safety of the exosomes based therapy with a particular focus on the Intervertebral Disk Disease, Stroke and Parkinson's Disease models. .

He previously served as Director of Neurosuregry, IRCCS Policlinico S.Matteo, Pavia, Italy.

In the recent years he has been Principal Investigator in Research Project “Diagnostic and prognostic value of exosomes isolated from patients with glioblastoma”.

Born in Milano, 8/9/1956, graduated cum laude in Medicine and Surgery at the University of Pavia (1981), Almo Collegio Borromeo alumn. Neurosurgery residency cum laude diploma at the University of Pavia (1986), Clinical Neurophysiology residency diploma (1992) at the University of Pavia. Assistant at the Department of Neurosurgery at the IRCCS Policlinico S.Matteo, Pavia, Italy (1988-1997). Vice Chairman, Department of Neurosurgery, Istituto Clinico Humanitas, Milan, Italy (1997-2012). Assistant at the Department of Neurosurgery at the IRCCS Policlinico S.Matteo, Pavia, Italy (2012-2013). Director of the Department of Neurosuregry at the IRCCS Policlinico S.Matteo, Pavia, Italy (2013-2017).

International experiences: January-March 1983: Neurosurgical Clinic of the University of Zurich; June-July 1989: University of California S. Francisco; January 1992: Orthopedic Clinic of the University of Bochum. Scientific Societies member: Society of Medical Surgery of Pavia, Italian Society of Neurosurgery since September, International Society for Cerebral Blood Flow and Metabolism, New York Academy of Sciences. Awards: - First Prize for the communication "Study of Prostaglandin D2 in the subarachnoid hemorrhage from ruptured intracranial aneurysm", at the National Symposium, Turin 23 October 1984; - Special National Award for Young Researchers "Albert Schweitzer" - 3M Italy, for the presentation: "Diagnosis of intracranial pathology pertaining neurosurgery by Computed Tomography in sagittal section," Caserta, Italy, April 1985; - "B.Guidetti" Prize – Italian Society of Neurosurgery for the presentation "Role of lipid peroxidation and antioxidant enzyme systems in the pathogenesis of neuronal damage resulting from SAH", September 1991. During his research activity Dr. Gaetani has been also supervisor of 1 PhD student in Chemistry and Pharmaceutical Technologies and 3 medical students and 2 intern in Neurosurgery. He is author and co-author of over 200 publications: over 130 papers published in international journals, 28 in national journals, 49 chapters in Congress Acts Volumes, 20 chapters in monographs and / or treaties. He is also author of 4 informative books on spine diseases for the general public.

Participation in international projects:- Participant at EORTC study 22845, "Determination of the effectiveness of radiation therapy in patients adults with supratentorial glioma slow growth";- Co-Investigator in the Multicenter International Trial "Study of the effectiveness of tirilazad Mesylate (U74006F) in subarachnoid hemorrhage", organized by the University of Virginia;- Principal Investigator of Center 22, International Multicenter Trial of the University of Cambridge (UK) “RESCUE ICP Study” (2009-2013);- Principal Investigator, Centre of Pavia, European Multicenter Trial "Evaluation of the I-Fuse in the treatment of unstable sacroiliac joints"(2013).

Participation in national projects:- Drafting and participant in the Special Project "Oncology", CNR, Contract 88.00791.44, "Single chemotherapy vs. multiple chemotherapy in the adjuvant treatment of malignant brain tumors";-Collaborator to the "Piano di Ricerca finalizzata per il settore Sanitario, Regione Lombardia, Area Diagnosi e Terapia, Settore Nuove Metodologie per la Terapia", Title: "Evaluation of the effectiveness of medical and surgical treatment in cerebrovascular disease", responsible Dr. R.Rodriguez y Baena, 1985-1988;- Participant in the Cooperative Multicentric Study organized by the Institute of Pharmacological Research "M.Negri", Milan "Italian Cooperative Study on Warning signs of Subarachnoid Hemorrhage", 1985-1986;- Cooperative Study on Nimodipine in prevention of vasospasm from subarachnoid hemorrhage, 1988-1989;- CARIPLO Project STEMDELIVERY, Head of S. Matteo Partner Unit, (2013)- Principal Investigator in the Clinical Trial “GLOWOMA: glioma lesions outlining with optics modification assistance: a phase II trial evaluating fluorescein-aided glioblastoma surgery” at IRCCS Policlinico S. Matteo of Pavia;- Principal Investigator in Research Project “Diagnostic and prognostic value of exosomes isolated from patients with glioblastoma” at IRCCS Policlinico S. Matteo of Pavia.

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