PUBLICATIONS
At PharmaExceed we are focused on developing new regenerative medicine therapies, spanning from cardiovascular to neurological, from tegumentary to respiratory.
View a list of publications related to our science.
Prediction of the mechanical response of a 3D (bio)printed hybrid scaffold for improving bone tissue regeneration by structural finite element analysis.
Scocozza, F., Di Gravina, G.M., Bari, E., Auricchio, F., Torre, M.L., Conti, M., Journal of the Mechanical Behavior of Biomedical Materials (2023), doi: https://doi.org/10.1016/j.jmbbm.2023.105822
cRGD-Functionalized Silk Fibroin Nanoparticles: A Strategy for Cancer Treatment with a Potent Unselective Naphthalene Diimide Derivative.
Pirota, V.; Bisbano, G.; Serra, M.; Torre, M.L.; Doria, F.; Bari, E.; Paolillo, M. Cancers 2023, 15, 1725. https://doi.org/10.3390/cancers15061725/
The Genes–Stemness– Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints.
Stella, G.M.; Marchiò, C.; Bari, E.; Ferrarotti, I.; Bertuccio, F.R.; Di Gennaro, A.; Abbott, D.M.; Putignano, P.; Campo, I.; Torre, M.L.; et al. Int. J. Mol. Sci. 2023, 24, 3496. https://doi.org/10.3390/ijms2404349
Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer.
Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Luca Mastracci, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Patrizio Castagnola, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci. Journal for ImmunoTherapy of Cancer 2023;11:e005916. http://dx.doi.org/10.1136/jitc-2022-005916
Silk Fibroin Bioink for 3D Printing in Tissue Regeneration: Controlled Release of MSC extracellular Vesicles.
Bari, E.; Di Gravina, G.M.; Scocozza, F.; Perteghella, S.; Frongia, B.; Tengattini, S.; Segale, L.; Torre, M.L.; Conti, M. Pharmaceutics 2023, 15, 383. https://doi.org/10.3390/pharmaceutics15020383
Three-Dimensional Bioprinted Controlled Release Scaffold Containing Mesenchymal Stem/Stromal Lyosecretome for Bone Regeneration: Sterile Manufacturing and In Vitro Biological Efficacy.
Bari, E.; Scocozza, F.; Perteghella, S.; Segale, L.; Sorlini, M.; Auricchio, F.; Conti, M.; Torre, M.L. Biomedicines 2022, 10, 1063. https://doi.org/10.3390/biomedicines10051063
A New Human Platelet Lysate for Mesenchymal Stem Cell Production Compliant with Good Manufacturing Practice Conditions Preserves the Chemical Characteristics and Biological Activity of Lyosecretome Isolated by Ultrafiltration.
Mareschi, K.; Banche Niclot, A.G.S.; Marini, E.; Bari, E.; Labanca, L.; Lucania, G.; Ferrero, I.; Perteghella, S.; Torre, M.L.; Fagioli, F. Int. J. Mol. Sci. 2022, 23, 4318. https://doi.org/10.3390/ijms23084318
Canine Mesenchymal Cell Lyosecretome Production and Safety Evaluation after Allogenic Intraarticular Injection in Osteoarthritic Dogs.
Mocchi, M.; Bari, E.; Dotti, S.; Villa, R.; Berni, P.; Conti, V.; Del Bue, M.; Squassino, G.P.; Segale, L.; Ramoni, R.; Torre, M.L.; Perteghella, S.; Grolli, S. Animals 2021, 11, 3271. https://doi.org/10.3390/ani11113271
Freeze-Dried Secretome (Lyosecretome) from Mesenchymal Stem/Stromal Cells Promotes the Osteoinductive and Osteoconductive Properties of Titanium Cages.
Bari, E.; Tartara, F.; Cofano, F.; di Perna, G.; Garbossa, D.; Perteghella, S.; Sorlini, M.; Mandracchia, D.; Giovannelli, L.; Gaetani, P.; TORRE, M.L.; Segale, L. Int. J. Mol. Sci. 2021, 22, 8445. https://doi.org/10.3390/ijms22168445
Freeze-Dried Mesenchymal Stem Cell-Secretome Pharmaceuticalization: Optimization of Formulation and Manufacturing Process Robustness.
Mocchi, M.; Bari, E.; Marrubini, G; Foglio Bonda, A.; Perteghella, S.; Tartara, F.; Cofano, F.; di Perna, G.; Giovannelli, L.; Mandracchia, D.; Sorlini, M.; Garbossa, D.; TORRE, M.L.; Segale, L. Pharmaceutics 2021, 13, 1129. https://doi.org/10.3390/pharmaceutics13081129
Equine Mesenchymal Stem/Stromal Cells Freeze-Dried Secretome (Lyosecretome) for the Treatment of Musculoskeletal Diseases: Production Process Validation and Batch Release Test for Clinical Use.
Mocchi, M.; Grolli, S.; Dotti, S.; Di Silvestre, D.; Villa, R.; Berni, P.; Conti, V.; Passignani, G.; Brambilla, F.; Bue, M.D.; Catenacci, L.; Sorrenti, M.; Segale, L.; Bari, E.; Mauri, P.; TORRE, M.L.; Perteghella, S. Pharmaceuticals 2021, 14, 553. https://doi.org/10.3390/ph14060553
Mesenchymal Stromal Cell Secretome for Post-COVID-19 Pulmonary Fibrosis: A New Therapy to Treat the Long-Term Lung Sequelae?
Bari, E.; Ferrarotti, I.; Saracino, L.; Perteghella, S.; TORRE, M.L.; Richeldi, L.; Corsico, A.G. Cells 2021, 10, https://doi.org/10.3390/cells10051203
Biohybrid Bovine Bone Matrix for Controlled Release of Mesenchymal Stem/Stromal Cell Lyosecretome: A Device for Bone Regeneration.
Bari, E.; Roato, I.; Perale, G.; Rossi, F.; Genova, T.; Mussano, F.; Ferracini, R.; Sorlini, M.; TORRE, M.L.; Perteghella, S. International Journal of Molecular Sciences 2021, 22, https://doi.org/10.3390/ijms22084064
3D Bioprinted Scaffolds Containing Mesenchymal Stem/Stromal Lyosecretome: Next Generation Controlled Release Device for Bone Regenerative Medicine.
Bari, E.; Scocozza, F.; Perteghella, S.; Sorlini, M.; Auricchio, F.; TORRE, M.L.; Conti, M. Pharmaceutics 2021, 13, https://doi.org/10.3390/pharmaceutics13040515
Silk Fibroin Nanoparticle Functionalization with Arg-Gly-Asp Cyclopentapeptide Promotes Active Targeting for Tumor Site-Specific Delivery.
Bari, E.; Serra, M.; Paolillo, M.; Bernardi, E.; Tengattini, S.; Piccinini, F.; Lanni, C.; Sorlini, M.; Bisbano, G.; Calleri, E.; TORRE, M.L.; Perteghella, S. Cancers 2021, 13, https://doi.org/10.3390/cancers13051185
GMP-compliant sponge-like dressing containing MSC lyo-secretome: Proteomic network of healing in a murine wound model.
Bari, E.; Di Silvestre, D.; Mastracci, L.; Grillo, F.; Grisoli, P.; Marrubini, G.; Nardini, M.; Mastrogiacomo, M.; Sorlini, M.; Rossi, R.; TORRE, M.L.; Mauri, P.; Sesana G.; Perteghella, S. European Journal of Pharmaceutics and Biopharmaceutics 2020, 155, 37-48, https://doi.org/10.1016/j.ejpb.2020.08.003
Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier?
Mocchi, M.; Dotti, S.; Del Bue, M.; Villa, R.; Bari, E.; Perteghella, S.; TORRE, M.L.; Grolli, S. Cells 2020, 9, https://doi.org/10.3390/cells9061453
Polyphenols-Loaded Sericin Self-Assembling Nanoparticles: A Slow-Release for Regeneration by Tissue-Resident Mesenchymal Stem/Stromal Cells.
Orlandi, G.; Bari, E.; Catenacci, L.; Sorrenti, M.; Segale, L.; Farago, S.; Sorlini, M.; Arciola, C.R.; TORRE, M.L.; Perteghella, S. Pharmaceutics 2020, 12, https://doi.org/10.3390/pharmaceutics12040381
Eco-sustainable silk sericin from by-product of textile industry can be employed for cosmetic, dermatology and drug delivery.
Orlandi, G.; Faragò, S.; Menato, S.; Sorlini, M.; Butti, F.; Mocchi, M.; Donelli, I.; Catenacci, L.; Sorrenti, M.L.; Croce, S.; Segale, L; TORRE, M.L.; Perteghella, S. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 2020, 12, 12, https://doi.org/10.1002/jctb.6441
Growth Factors Delivery System for Skin Regeneration: An Advanced Wound Dressing. Pharmaceutics
Nardini, M.; Perteghella, S.; Mastracci, L.; Grillo, F.; Marrubini, G.; Bari, E.; Formica, M.; Gentili, C.; Cancedda, R.; TORRE, M.L.; Mastrogiacomo, M. 2020, 12, https://doi.org/10.3390/pharmaceutics12020120
Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use
Bari E, Ferrarotti I, Saracino L, Perteghella S, Torre ML, Corsico AG, Cells 2020, April 9.
Mesenchymalstem/stromal cell secretome for lung regeneration: the long way through “pharmaceuticalization” for the best formulation.
Bari E, Ferrarotti I, Torre ML, Corsico AG, Perteghella S, Journal of Controlled Release, 2019
Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration.
Bari E, Ferrarotti I, Di Silvestre D, Grisoli P, Barzon V, Balderacchi A, Torre ML, Rossi R, Mauri P, Corsico AG, Perteghella S. Cells. 2019 Aug 23;8(9).
Paclitaxel-loaded silk fibroin nanoparticles: method validation by UHPLC-MS/MS to assess an exogenous approach to load cytotoxic drugs.
Perteghella S, Sottani C, Coccè V, Negri S, Cavicchini L, Alessandri G, Cottica D, Torre ML, Grignani E, Pessina A (2019).
Freeze-dried and GMP-compliant pharmaceuticals containing mesenchymal exosomes for acellular MSC immunomodulant therapy.
Bari E, Perteghella S, Catenacci L, Sorlini M, Croce S, Mantelli M, Avanzini M A, Sorrenti M, Torre ML.
Nanomedicine 2019
Silk fibroin nanoparticles for Celecoxib and Curcumin delivery: ROS-scavenging and anti-inflammatory activities in an in vitro model of osteoarthritis.
Crivelli B, Bari E, Perteghella S, Catenacci L, Sorrenti M, Mocchi M, Faragò S, Tripodo G, Prina-Mello A,Torre ML.
Journal of Pharmaceutics and Biopharmaceutics 2019
Pilot Production of Mesenchymal Stem/Stromal Freeze-Dried Secretome for Cell-Free Regenerative Nanomedicine: A Validated GMP-Compliant Process.
Bari E, Perteghella S, Di Silvestre D, Sorlini M, Catenacci L, Sorrenti M, Marrubini G, Rossi R, Tripodo G, Mauri P, Marazzi M, Torre ML.
Cells. 2018 Oct 30;7(11).
Association of silk sericin and platelet lysate: Premises for the formulation of wound healing active medications.
Bari E, Perteghella S, Faragò S, Torre ML.
Int J Biol Macromol. 2018 Nov;119:37-47.
https://www.sciencedirect.com/science/article/pii/S0141813018330083?via%3Dihub
In vitro efficacy of silk sericin microparticles and platelet lysate for intervertebral disk regeneration.
Bari E, Perteghella S, Marrubini G, Sorrenti M, Catenacci L, Tripodo G, Mastrogiacomo M, Mandracchia D, Trapani A, Faragò S, Gaetani P, Torre ML
Int J Biol Macromol. 2018 Oct 15;118(Pt A):792-799.
https://www.sciencedirect.com/science/article/pii/S0141813018315824?via%3Dihub
Silk nanoparticles: from inert supports to bioactive natural carriers for drug delivery.
Crivelli B, Perteghella S, Bari E, Sorrenti M, Tripodo G, Chlapanidas T, Torre ML.
Soft Matter. 2018 Jan 24;14(4):546-557.
https://pubs.rsc.org/en/Content/ArticleLanding/2018/SM/C7SM01631J#!divAbstract
Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system.
Crivelli B, Chlapanidas T, Perteghella S, Lucarelli E, Pascucci L, Brini AT, Ferrero I, Marazzi M, Pessina A, Torre ML
Italian Mesenchymal Stem Cell Group (GISM). J Control Release. 2017 Sep 28;262:104-117. doi: 10.1016/j.jconrel.2017.07.023.
http://www.sciencedirect.com/science/article/pii/S0168365917307320?via%3Dihub
Stem cell-extracellular vesicles as drug delivery systems: New frontiers for silk/curcumin nanoparticles.
Perteghella S, Crivelli B, Catenacci L, Sorrenti M, Bruni G, Necchi V, Vigani B, Sorlini M, Torre ML, Chlapanidas T.
Int J Pharm. 2017 Mar 30;520(1-2):86-97. doi: 10.1016/j.ijpharm.2017.02.005. Epub 2017 Feb 2.
http://www.sciencedirect.com/science/article/pii/S0378517317300868?via%3Dihub
Mesenchymal stromal cells loading curcumin-INVITE-micelles: a drug delivery system for neurodegenerative diseases. Colloids Surf B Biointerfaces.
Tripodo G, Chlapanidas T, Perteghella S, Vigani B, Mandracchia D, Trapani A, Galuzzi M, Tosca MC, Antonioli B, Gaetani P, Marazzi M, Torre ML.
2015 Jan 1;125:300-8. doi: 10.1016/j.colsurfb.2014.11.034. Epub 2014 Dec 2.
http://www.sciencedirect.com/science/article/pii/S0927776514006596?via%3Dihub