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At PharmaExceed we are focused on developing new regenerative medicine therapies, spanning from cardiovascular to neurological, from tegumentary to respiratory. 

View a list of  publications related to our science.

Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use

Bari E, Ferrarotti I, Saracino L, Perteghella S, Torre ML, Corsico AG,  Cells 2020, April 9.

Mesenchymalstem/stromal cell secretome for lung regeneration: the long way through “pharmaceuticalization” for the best formulation.

Bari E, Ferrarotti I, Torre ML, Corsico AG, Perteghella S,  Journal of Controlled Release, 2019

Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration.

Bari E, Ferrarotti I, Di Silvestre D, Grisoli P, Barzon V, Balderacchi A, Torre ML, Rossi R, Mauri P, Corsico AG, Perteghella S. Cells. 2019 Aug 23;8(9).

Paclitaxel-loaded silk fibroin nanoparticles: method validation by UHPLC-MS/MS to assess an exogenous approach to load cytotoxic drugs.

Perteghella S, Sottani C, Coccè V, Negri S, Cavicchini L, Alessandri G, Cottica D, Torre ML, Grignani E, Pessina A (2019).

Freeze-dried and GMP-compliant pharmaceuticals containing mesenchymal exosomes for acellular MSC immunomodulant therapy.

Bari E, Perteghella S, Catenacci L, Sorlini M, Croce S, Mantelli M, Avanzini M A, Sorrenti M, Torre  ML.

Nanomedicine 2019

Silk fibroin nanoparticles for Celecoxib and Curcumin delivery: ROS-scavenging and anti-inflammatory activities in an in vitro model of osteoarthritis.

Crivelli B, Bari E, Perteghella S, Catenacci L, Sorrenti M, Mocchi M, Faragò S, Tripodo G, Prina-Mello A,Torre ML.

Journal of Pharmaceutics and Biopharmaceutics 2019

Pilot Production of Mesenchymal Stem/Stromal Freeze-Dried Secretome for Cell-Free Regenerative Nanomedicine: A Validated GMP-Compliant Process.

Bari E, Perteghella S, Di Silvestre D, Sorlini M, Catenacci L, Sorrenti M, Marrubini G, Rossi R, Tripodo G, Mauri P, Marazzi M, Torre ML.

Cells. 2018 Oct 30;7(11).

Association of silk sericin and platelet lysate: Premises for the formulation of wound healing active medications.

Bari E, Perteghella S, Faragò S, Torre ML.

Int J Biol Macromol. 2018 Nov;119:37-47.

In vitro efficacy of silk sericin microparticles and platelet lysate for intervertebral disk regeneration. 

Bari E, Perteghella S, Marrubini G, Sorrenti M, Catenacci L, Tripodo G, Mastrogiacomo M, Mandracchia D, Trapani A, Faragò S, Gaetani P, Torre ML

Int J Biol Macromol. 2018 Oct 15;118(Pt A):792-799.

Silk nanoparticles: from inert supports to bioactive natural carriers for drug delivery.

Crivelli B, Perteghella S, Bari E, Sorrenti M, Tripodo G, Chlapanidas T, Torre ML. 

Soft Matter. 2018 Jan 24;14(4):546-557.!divAbstract

Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system.

Crivelli B, Chlapanidas T, Perteghella S, Lucarelli E, Pascucci L, Brini AT, Ferrero I, Marazzi M, Pessina A, Torre ML 

Italian Mesenchymal Stem Cell Group (GISM). J Control Release. 2017 Sep 28;262:104-117. doi: 10.1016/j.jconrel.2017.07.023.

Stem cell-extracellular vesicles as drug delivery systems: New frontiers for silk/curcumin nanoparticles.

Perteghella S, Crivelli B, Catenacci L, Sorrenti M, Bruni G, Necchi V, Vigani B, Sorlini M, Torre ML, Chlapanidas T. 

Int J Pharm. 2017 Mar 30;520(1-2):86-97. doi: 10.1016/j.ijpharm.2017.02.005. Epub 2017 Feb 2.

Mesenchymal stromal cells loading curcumin-INVITE-micelles: a drug delivery system for neurodegenerative diseases. Colloids Surf B Biointerfaces. 

Tripodo G, Chlapanidas T, Perteghella S, Vigani B, Mandracchia D, Trapani A, Galuzzi M, Tosca MC, Antonioli B, Gaetani P, Marazzi M, Torre ML. 

2015 Jan 1;125:300-8. doi: 10.1016/j.colsurfb.2014.11.034. Epub 2014 Dec 2.

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